Although life expectancy is increasing, healthy life expectancy is not increasing at the same pace, leading to more years being lived in poor health. Therefore, the disease burden is shifting to chronic disease, with age being the main driver for chronic aging-related diseases.sThe average amount of time spent living with chronic disease in industrialized countries is about 11 years.

As a result, there is a growing focus on research that targets aging, for example the investigation of geroprotectors, compounds capable of slowing the aging process and delaying the onset of multiple tissue dysfunction and aging-related diseases.